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Mechanisms of Beta Cell Failure: Implications for Durable Beta Cell Replacement

Concurrent
Chair Valeria Sordi (IT)

Learning Objectives

  1. Highlight beta cell-intrinsic mechanisms that can limit durable graft function.
  2. Explain how beta cell stress and immunogenicity may influence graft vulnerability and recurrent autoimmunity.
  3. Translate lessons from clinical islet transplantation into strategies for next-generation beta cell replacement.

Presentations

Peter Thompson (CA)
Senescent but surviving: beta cell persistence and dysfunction as barriers to durable graft function
Peter Thompson (CA)
Bio
Stress, autophagy and immunogenicity: how beta cell state may shape graft vulnerability
Amelia Linnemann (US)
Bio
Why islet grafts fail: Clinical lessons for durable beta cell replacement
James Shaw (GB)
Bio

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Mechanisms of Beta Cell Failure: Implications for Durable Beta Cell Replacement

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https://www.app.ipita2027.org/program_view/timeslot/32